Creatine

Creatine is nitrogen-containing compound stored mainly as phosphocreatine in muscle. It is used in supplements positioned for sports performance; muscle, although evidence strength and legally permitted claims depend on the exact form, dose and jurisdiction.

Workout performance
Brain health
Metabolism

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Origin of Ingredient

made endogenously and found in meat/fish; supplements usually use manufactured creatine monohydrate

History of Ingredient

Creatine moved from food, biochemical or specialist use into modern supplements as purification, fermentation, extraction and standardisation technologies developed.

Scientific Makeup of Ingredient

methylguanidinoacetic acid; phosphocreatine buffers ATP demand

UK Legal Claim

• Creatine increases physical performance in successive bursts of short-term, high intensity exercise. Conditions: 3 g creatine/day; intended for adults performing high-intensity exercise. Consumer information must state that the beneficial effect is obtained with 3 g/day.

EU Legal Claim

US Legal Claim

FDA does not pre-approve ordinary dietary-supplement structure/function claims. Example for regulatory review only (NOT FDA-approved wording): “Supports normal cognitive/brain function.” The marketer must hold substantiation, avoid disease claims, use the DSHEA disclaimer and notify FDA within 30 days after first marketing.

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August 24, 2024

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